Advances in Pharmaceutical Research:
From Lead Discovery to Drug Manufacturing- Spring 2003
Syllabus Schedule Links Course Homepage
Daryl R. Sauer, Ph.D., Abbot Laboratories
Norbeck, Daniel W. - Progress toward the total synthesis of polyether ionophore antibiotics. CIT theses ; 1985.
Standardization Protocols and Optimized Precursor Sets for the Efficient Application of Automated Parallel Synthesis to Lead Optimization: A Mitsunobu Example Gentles, R. G.; Wodka, D.; Park, D. C.; Vasudevan, A.; J. Comb. Chem.; 2002; 4(5); 442-456. - Supporting Information
Purification of HTOS libraries by supercritical fluid chromatography Hochlowski J, Olson J, Pan J, Sauer D, Searle P, Sowin T JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES 26 (3): 333-354 2003
Abstract:
A commercially available preparative scale supercritical fluid chromatography (SFC) system has been customized and applied to the purification of high throughput organic synthesis (HTOS) libraries. Pilot reactions allow the triage between HPLC and SFC as the most appropriate purification technique, and when applicable, SFC has been proven to offer advantages in terms of decreased purification and sample dry-down time and purification capabilities, somewhat complementary to HPLC. Standardized chemistry-specific SFC methods have been determined and HTOS pilot reactions allow refinement of these standard methods to optimal conditions for a specific library core.
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